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歷 年 稿 件 內 容
 
*類別:
* 姓名: 曾碧緣
投稿種類: 壁報
*中文投稿標題: Oral administrations of FIP-fve has the effect of inhibiting allergen (OVA)-induced
*中文作者姓名列:
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* 投稿摘要: The allergy is dependent on the balance between Th1 and Th2. The fungal immunodulatory protein (FIP-fve) was isolated from Flammulina velutipes. FIP-fve has been demonstrated to skew the response to Th1 cytokine production. We investigated whether oral administrations of FIP-fve inhibited allergen (OVA)-induced chronic airway inflammation in the mouse asthma model. After intranasal challenge with OVA, the airway inflammation and hyperresponsiveness were determined by bronchoalveolar lavage fluid (BALF) analysis and ELISA assay. Both pre-treated and post-treated with FIP-fve suppressed the airway hyperresponsiveness by methacholine challenge and significantly decreased the number of infiltrating inflammatory cells and Th2 cytokines in bronchoalveolar lavage fluid (BALF) and serum compared with the OVA sensitized mice. In addition, FIP-fve reduced OVA-specific IgE levels in serum. FIP-fve markedly alleviated the OVA-induced airway hyperresponsiveness (AHR) to inhaled methacholine. Based on lung histopathological studies using hematoxylin and Liu’s staining, FIP-fve inhibited inflammatory cell infiltration compared with the OVA-sensitized mice. Oral FIP-fve had an anti-inflammatory effect on OVA-induced airway inflammations and might posses the potential for alternative therapy for allergic airway diseases.
*關鍵字1 : fungal immunodulatory protein
*關鍵字2 : FIP-fve
*關鍵字3 : asthma
*關鍵字4 : Th2 cytokines
*關鍵字5 : anti-inflammatory effect
* 服務機關:
* 第一作者: 曾碧緣
* 身分字號: *****48746
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