2025-06-30　恭賀 邱仁祥醫檢師 當選『第17屆南投縣醫檢師公會理事長』!!! 　 2025-06-02　恭賀 洪經勝醫檢師 當選『第17屆台北市醫檢師公會理事長』!!! 　 2025-05-15　✪114年度實驗室開發檢測之資深暨新進實驗室人員訓練課程✪請參閱最新消息公告！ 　 2025-04-16　恭賀 黃碧標醫檢師 當選『第16屆臺中市大臺中醫檢師公會理事長』!!! 　 2023-07-01　會員如有權益相關問題及對本會有任何建議或意見回饋，歡迎利用電子信箱或致電本會，謝謝您!! 　 2015-02-02　醫事檢驗師宣誓誓詞，誓詞內容請至文件下載區查閱，並請協助推廣，謝謝！ 　

:::

歷 年 稿 件 內 容
 
*類別：
* 姓名： 陸德容
投稿種類： 壁報
*中文投稿標題： MST3 is a novel candidate gene for inhibition of Na reabsorption in kidney and hypertension
*中文作者姓名列：
*中文服務單位：
*英文投稿標題：
*英文作者姓名列：
*英文服務單位：
* 投稿摘要： By immunohistochemistry, a mammalian ste20-like kinase 3 (MST3), was mostly stained in the medulla of the kidney of B6 mice and Wistar-Kyoto (WKY) rats. Furthermore, MST3 levels were markedly reduced in the principle cell in the medulla of spontaneously hypertensive rats (SHR) compared with WKY controls. The degree of the reduction was augmented with prominent apical site of the principle cells of the collecting duct. The MST3 level was also measured before (age 3-4 weeks) and after (age 12-14 weeks) the development of hypertension and in SHR and age-matched WKY controls by western. 12-14-week-old SHR also had significantly reduced MST3 in outer and inner medulla compared with those of WKY controls. The difference in MST3 levels already existed between prehypertensive SHR and WKY rats. In vivo, the urinary sodium and water excretion from the urine was higher in constitutive MST3 transgenic mice on high salt diet compared to WT-MST3 mice on same diet. It raises the possibility that decreased inner medullary collecting duct production of MST3 could contribute to inappropriate sodium and water retention. Finally, 3B5 cells expressing WT-MST3 persists to NaCl but not urea induced perturbing effects of hyperosmolality at osmotic concentrations of 1,200 mOsm/Kg H2O. The present studies show for the first time that MST3 decreasing in inner medullary collecting duct is an intermediate kinase to inhibit urinary sodium retention in hypertension. The identification of MST3 might uncover a brand new gene that could prosper into a novel diagnostic and/or therapeutic target for hypertension. p.s. I regret that there is no data from human beings. We may wait till the chance comes and perform the experiment in the future.
*關鍵字1 ： MST3
*關鍵字2 ： Na reabsorption
*關鍵字3 ： hypertension
*關鍵字4 ： ste20 kinase
*關鍵字5 ： kidney
* 服務機關：
* 第一作者： 陸德容
* 身分字號： *****21403
其他投稿作者：
身分字號：  
其他投稿作者：
身分字號：  
其他投稿作者：
身分字號：  
其他投稿作者：
身分字號：  
其他投稿作者：
身分字號：  
其他投稿作者：
身分字號：  
其他投稿作者：
身分字號：  
上傳稿件檔：
 開啟檔案
審查委員意見： acceptable after minor revision of typo & grammar errors.
審查委員意見： 本篇是藉由老鼠實驗提出MST3可以作為高血壓的診斷標誌或治療的標的,沒有人類的相關資料.
主任委員意見： 無意見
 
回上頁