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歷 年 稿 件 內 容
 
*類別：
* 姓名： 張懿欣
投稿種類： 壁報
*中文投稿標題： Role of Collapsin Response Mediator Protein 2 in Lipid and Glucose Metabolism
*中文作者姓名列：
*中文服務單位：
*英文投稿標題：
*英文作者姓名列：
*英文服務單位：
* 投稿摘要： Insulin resistance is an early and important defect associated with type 2 diabetes mellitus (T2DM). Dysregulated cytoskeleton has been suggested to result in insulin resistance and T2DM. Collapsin response mediator protein 2 (CRMP2), a regulator protein in microtubules dynamics, is known to be regulated by glycogen synthase kinase-3 beta (GSK-3b), an important mediator in the secretion and signaling of insulin and translocation of glucose transporter type 4 (GLUT4). In addition to GLUT4, trafficking of lipid droplets (LDs) in adipocytes is also regulated by the dynamic of cytoskeleton. Accordingly, we hypothesize that CRMP2 may play an important role in vesicle trafficking required for GLUT4 translocation as well as for the fusion and accumulation of LDs in adipocytes. In this context, dysregulated CRMP2 expression may lead to abnormality in response to insulin stimulation, which then contributes to T2DM pathogenesis. The aims of this study are to investigate the expression patterns of CRMP2 in adipogenesis and the effects of CRMP2 on glucose and lipid metabolism in adipocytes. Our results showed that differential CRMP2 protein expression patterns were observed during the adipogenic process. Knockdown of CRMP2 expression by siRNA resulted in enhanced lipid accumulation and glucose uptake in adipocytes. The above results suggest that CRMP2 may downregulate glucose uptake and lipid metabolism in adipocytes, and therefore, participate in the diabetic pathogenesis.
*關鍵字1 ： Type 2 diabetes mellitus
*關鍵字2 ： Collapsin response mediator protein 2
*關鍵字3 ： Adipogenesis
*關鍵字4 ： Glucose metabolism
*關鍵字5 ： Lipid metabolism
* 服務機關：
* 第一作者： 許瑋庭
* 身分字號： *****69903
其他投稿作者： 蕭明裕
身分字號： *****12374
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審查委員意見： 建議轉頭分子醫學組較為適當
審查委員意見： 無意見
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