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歷 年 稿 件 內 容
 
*類別：
* 姓名： 王秋惠
投稿種類： 壁報
*中文投稿標題： 先天免疫基因多型性與結核分枝桿菌感染之感受性有關
*中文作者姓名列：
*中文服務單位：
*英文投稿標題：
*英文作者姓名列：
*英文服務單位：
* 投稿摘要： Tuberculosis (TB) recently has re-emerged as a major public health threat worldwide. However, there is strong evidence that host genetic factors influence individual susceptibility to tuberculosis. The association between polymorphisms of innate immunity receptors cluster of CD14, mannose-binding lectin (MBL), Toll-like receptor (TLR)-7 and TLR8 with susceptibility in 78 patients with active TB and 243 healthy controls were investigated. Genotyping for CD14-159, TLR7 IVS2-151, TLR8-129 were performed by polymerase chain reaction-restriction fragment length polymorphism methods, MBL polymorphisms were analyzed by TaqMan 5´ nuclease assay in Real-Time PCR System. In this study, C allele in TLR8 promoter -129 was demonstrated to be significantly higher in patients with TB infection compared to controls (22.1% vs. 9.5%; OR:2.71; p=0.005). The B allele in MBL codon 54 conferred a protective role against TB in our study population with a significant difference (OR = 0.58; p = 0.05). But subjects with H allele in MBL-550 had a higher risk to susceptibility to TB (OR = 1.84; p = 0.0006). However, no significantly association between CD14 -260 G>C and TLR7 IVS2-151 G>A polymorphisms with TB infection was found. In conclusion, our results provide an evidence of the association between MBL and TLR8 gene polymorphism with susceptibility to TB infection, but not the SNPs of CD14 and TLR7 in our population.
*關鍵字1 ： Tuberculosis
*關鍵字2 ： Toll-like receptor 8
*關鍵字3 ： mannose-binding lectin
*關鍵字4 ： polymorphism
*關鍵字5 ： CD14
* 服務機關：
* 第一作者： 王秋惠
* 身分字號： *****67561
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 開啟檔案
審查委員意見： OK.
審查委員意見： 作者提供了病患之MBL與TLR8的基因多樣性分析有助於了解病患對TB的易感性
主任委員意見：
 
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