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歷 年 稿 件 內 容
 
*類別: C組-生化、血清免疫
* 姓名: 黃雅芳
投稿種類: 壁報
*中文投稿標題: 紅龍果萃取物抑制人類乳癌細胞生長之訊息路徑研究
*中文作者姓名列: 黃雅芳1、姜泰安2*、周庭葦2、幸良蘭1、李文琮3、林川傑4、王保隆5、張旭男6、王淑貞7、吳佩芬8
*中文服務單位: 財團法人屏東基督教醫院檢驗科1、中華醫事科技大學醫學檢驗生物技術系2、郭綜合醫院病理檢驗科3、國仁醫院檢驗科4、瑩芳有限公司5、高雄榮總台南分院內科部肝膽胃腸科6、台南市立醫院檢驗科7、大仁科技大學環境與職業安全衛生系8
*英文投稿標題: The signal transduction pathway of growth inhibition by Hylocereus Polyrhizus extracts in Human Breast Cancer Cell
*英文作者姓名列: Ya-Fang Huang1; Tai-An Chiang2; Ting-Wei Chou2; Liang-Lan Hsing2; Wen-Tsung Lee3; Chuan-Ja Lin4; Pao-Lung Wang5; Shiuh-Nan Chang6; Shu-Chen Wang7; Pei-Fen Wu8
*英文服務單位: Department of Clinical Laboratory, Pingtung Christian Hospital, Pingtung, Taiwan1; The Department of Medical Laboratory Science and Biotechnology, Chung-Hwa University of Medical Technology2; Department of Laboratory Medicine, Guo General Hospital3; Department of Laboratory Medicine, Golden Hospital4; In Fung Corporation Ltd5; Department of Gastroenterology, Kaohsiung Veterans General Hospital,Tainan Branch6; Department of Laboratory Medicine, Tainan Municipal Hospital7; Department of Environmental Science and Occupational Safety and Hygiene, Tajen University8
* 投稿摘要: Epidemiological studies have indicated that breast cancer is one of the leading cancer of death in Taiwan. At patient, surgical therapy and chemotherapy are the major strategies for the cure of breast cancer. The chemotherapeutic drugs are usually designed to induce cancer cell death via cell cycle arrest and/or apoptosis pathways. In this study, we used an extracts of Hylocereus Polyrhizus to inhibit breast cancer cell proliferation and tumor growth, and investigate the underlying molecular mechanisms. Human breast cancer cell lines (MCF-7) was used in this study, and found Hylocereus Polyrhizus extracts significantly decreased cell proliferation by a dose-dependent manner in cells. Flow cytometry demonstrated that Hylocereus Polyrhizus extracts induced cell cycle arrest at G0/G1 phase. When analysis the expression of cell cycle-related proteins, we found that Hylocereus Polyrhizus extracts increased caspase3/7/9 and Cyt-C in a dose-dependent manner. These results suggest that Hylocereus Polyrhizus extracts could inhibit human breast cancer cell proliferation and tumor growth, and might be a potential drug for chemotherapy.
*關鍵字1 : Hylocereus Polyrhizus extracts
*關鍵字2 : apoptosis
*關鍵字3 : breast cancer
*關鍵字4 : chemotherapy
*關鍵字5 : cell cycle
* 服務機關:
* 第一作者: 黃雅芳
* 身分字號: *****94721
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審查委員意見: OK
審查委員意見: 同意
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