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歷 年 稿 件 內 容
 
*類別: C組-生化、血清免疫
* 姓名: 林川傑
投稿種類: 壁報
*中文投稿標題: 探討桑黃萃取物抑制肺癌細胞研究
*中文作者姓名列: 林川傑1、姜泰安2*、周庭葦2、李文琮3、王保隆4、張旭男5、王淑貞6、吳佩芬7*
*中文服務單位: 國仁醫院檢驗科1、中華醫事科技大學醫學檢驗生物技術系2、郭綜合醫院病理檢驗科3、瑩芳有限公司4、高雄榮總台南分院內科部肝膽胃腸科5、台南市立醫院檢驗科6、大仁科技大學環境與職業安全衛生系7
*英文投稿標題: The growth inhibition of lung cancer cell by phellinus igniarius extracts
*英文作者姓名列: Chuan-Ja Lin1; Tai-An Chiang2; Ting-Wei Chou2; Wen-Tsung Lee3; Pao-Lung Wang4; Shiuh-Nan Chang5; Shu-Chen Wang6; Pei-Fen Wu7
*英文服務單位: Department of Laboratory Medicine, Golden Hospita1; The Department of Medical Laboratory Science and Biotechnology, Chung-Hwa University of Medical Technology2; Department of Laboratory Medicine, Guo General Hospital3;In Fung Corporation Ltd4; Department of Gastroenterology, Kaohsiung Veterans General Hospital,Tainan Branch5; Department of Laboratory Medicine, Tainan Municipal Hospital6; Department of Environmental Science and Occupational Safety and Hygiene, Tajen University7
* 投稿摘要: Phellinus igniarius has been published recently for multiple medical purposes as an effective treatment as cancer therapy and hepato-protection. The potential anti-carcinogenesis-effect extracts from Phellinus igniarius was confirmed by our previous study. However, no reference was published for investigating the anti-lung cancer by the potential anti-carcinogenesis-effect extracts. In this study, the inhibition of lung cancer cell proliferation and tumor growth by phellinus igniarius extracts was performed to investigate the underlying molecular mechanisms. The results indicated that phellinus igniarius extracts significantly decreased cell proliferation by a dose-dependent manner in Human lung cancer cell lines (A549). Flow cytometry analysis demonstrated that phellinus igniarius extracts induced cell cycle arrest at G0/G1 phase. phellinus igniarius extracts increased the apoptotic protein caspase3/7/9 and decreased the anti-apoptotic protein BCL in a dose-dependent manner. These results suggest that phellinus igniarius extracts could inhibit human lung cancer cell proliferation and tumor growth, and might be a potential drug for chemotherapy.
*關鍵字1 : phellinus igniarius extracts
*關鍵字2 : growth inhibition
*關鍵字3 : lung cancer
*關鍵字4 : chemotherapy
*關鍵字5 : cell cycle
* 服務機關:
* 第一作者: 林川傑
* 身分字號: *****82011
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