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歷 年 稿 件 內 容
 
*類別： D組-分子醫學
* 姓名： 吳秀容
投稿種類： 壁報
*中文投稿標題： NDC80在大腸癌進展中的角色與造成基因體不穩定及當成治療標的的可行性
*中文作者姓名列： 吳秀容1、梁頌文2、許詔文3、陳懷星4、吳京璉4、蔡薷毅4、潘弘偉4
*中文服務單位： 高雄榮民總醫院病理檢驗部1,高雄榮民總醫院放射腫瘤部2,高雄榮民總醫院外科部大腸直腸科3, 高雄榮民總醫院教學研究部4
*英文投稿標題： The Role of NDC80 in Colon Cancer Progression, Altered Genomic Instability and Its Therapeutic Potential
*英文作者姓名列： Shiou-Rong Wu 1;Chung-Man Leung2; Chao-Wen Hsu 3;Huai-Hsing Chen 4;Jin-Lian Wu 4;Ju-I Tsai 4;Hung-Wei Pan 4
*英文服務單位： Department of Pathology and Laboratory Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan1, Department of Radiation Oncology, Kaohsiung Veteran General Hospital, Kaohsiung, Taiwan2, ivision of Colorectal Surgery, Department of Surgery, Kaohsiung Veteran General Hospital, Kaohsiung, Taiwan3, Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan4
* 投稿摘要： Aneuploidy and chromosomal instability (CIN) are common abnormalities in human cancer. To elucidate the correlation between CIN and colorectal cancer (CRC) might serve as diagnostic or prognostic markers and form the basis for novel therapeutic strategies. In this study, we figure out 58 chromosome segregation genes overexpression in CRC. Three of 58 chromosome segregation genes, NDC80, Nuf2 and SPC25 belong to the NDC80 complex, which complex play a critical role in chromosome segregation. In order to understand the NDC80 expression in CRC tissue, Using IHC stain for NDC80 protein detection, 90 out of 141 CRCs had high NDC80 expression. Histopathologically, NDC80 high-expression closely correlated with high-pathological T-staging (T2~T3), high-stage tumors (stages II, III) and lower 12-year survival in stage II and III CRC patients. To further elucidate the role of NDC80 and genomic instability in colon cancer cells, the RAPD-PCR assay for genetic alteration detection indicated there were higher genetic alterations in HT-29 (aneuploidy cell) with high NDC80 expression, but not in DLD-1 (diploidy cell) with low NDC80 expression. Furthermore, there were differential genetic alteration pattern between the high- and low-NDC80 expressions by using the DNA samples extracted from FFPE CRC tissue sections. These results indicated the NDC80 expression level should be correlated to the genetic alteration. Moreover, knockdown of NDC80 in CRC cells lead to cancer cell growth inhibition and multi-nucleated cells indicated targeting NDC80 has a therapeutic potential in CRC.
*關鍵字1 ： Aneuploidy
*關鍵字2 ： chromosomal instability
*關鍵字3 ： colorectal cancer
*關鍵字4 ： NDC80
*關鍵字5 ： RAPD-PCR
* 服務機關：
* 第一作者： 吳秀容
* 身分字號： *****64738
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