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歷 年 稿 件 內 容
 
*類別： B組-微生物、病毒
* 姓名： 張懿欣
投稿種類：
*中文投稿標題： 2002-2014年台灣中部地區分枝桿菌臨床分離菌株盛行率與抗藥性之趨勢變化
*中文作者姓名列： 蕭明裕1、李名世2,3、黃天麟2、蔡振寧3、張懿欣4
*中文服務單位： 1弘光科技大學醫護學院系基礎醫學組、2中山醫學大學附設醫院檢驗科、3中山醫學大學醫學檢驗暨生物技術學系、4國立陽明大學醫學生物技術暨檢驗學系
*英文投稿標題： Mycobacterial Prevalence and Antibiotic Resistance Frequency Trends of Mycobacterial Clinical Isolates in Central Taiwan from 2002 to 2014
*英文作者姓名列： Ming-Yuh Shiau1, Ming-Shih Lee2,3, Tian-Lin Huang2
*英文服務單位： 1Department of Nursing, College of Medicine and Nursing, Hungkuang University, Taichung, 2Clinical Laboratory, Chung Shan Medical University-Hospital, Taichung, 3School of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung, 4Department of Biotechnology and Laboratory Science in Medicine, National Yang-Ming University, Taipei, Taiwan
* 投稿摘要： Background. Tuberculosis, caused by Mycobacterium tuberculosis complex (MTBC) infections, is one of the most widespread infectious diseases worldwide. Non-tuberculous mycobacteria (NTM) also cause chronic pulmonary infections, however, NTM infection is generally overlooked. Methods. This study analyzed the frequencies of MTBC and NTM clinical isolates from 181,132 specimens obtained from patients in Taiwan suspected of having a pulmonary mycobacterial infection from 2002 to 2014. The resistant rates to four first-line antibiotics (isoniazid, ethambutol, rifampicin and streptomycin) of 9,079 clinical MTBC isolates were also examined by the modified agar proportion method. Results. Overall, the mycobacterial isolation rate was 8.65%, and this consisted of MTBC isolation rate of 5.01% and NTM isolation rate of 3.63%. The prevalence of MTBC isolates among the identified mycobacterial strains could be seen to decrease significantly from 82.5% in 2002 to 41.18% in 2014. Notably, the corresponding NTM prevalence increased 3.36 fold from 17.54% in 2002 to 58.82% in 2014. The frequencies of MTBC and NTM isolates showed a reciprocal trend with the crossing-over occurring in the years 2010 and 2011. While the resistance rates of the MTBC isolates to isoniazid and streptomycin were relatively stable over the study period, resistance rates of the MTBC isolates against rifampicin and ethambutol fluctuated across the study period. Overall, the incidence of multidrug resistance was relatively consistent at about 1.74%. Conclusions. The diagnosis, identification and susceptibility tests for NTM should be standardized and integrated into appropriate clinical settings in order to cope with the increase in NTM infections. In addition, the documentation of the antibiotic resistance rates of MTBC clinical isolates to the antibiotic treatments most often clinically prescribed over a decade provides valuable clues and reference points for effective mycobacterial control.
*關鍵字1 ： tuberculosis,
*關鍵字2 ： Mycobacterium tuberculosis
*關鍵字3 ： non-tuberculous mycobateria
*關鍵字4 ： antimicrobial resistance
*關鍵字5 ： mycobacterial prevalence
* 服務機關：
* 第一作者： 蕭明裕
* 身分字號： *****12374
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上傳稿件檔：
審查委員意見： 檢驗室資料分析 分析對象不明 菌株數不明 都只有百分比
審查委員意見： 不OK
主任委員意見：
 
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