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歷年稿件內容

*類別：	D組-分子醫學
* 姓名：	楊順發
投稿種類：	壁報
*中文投稿標題：	醛固酮合成基因其基因多型性與冠動脈疾病的相關性探討
*中文作者姓名列：	周祈宏1,2,翁國昌3, 楊順發1,4 , 邱慧玲5,6
*中文服務單位：	中山醫學大學醫學研究所1, 員林員生醫院心臟科2，中山醫學大學附設醫院內科部3，中山醫學大學醫學研究部臨床研究中心4，中山醫學大學附設醫院檢驗科5，中山醫學大學醫學檢驗暨生物技術學系6，台中，台灣
*英文投稿標題：	Aldosterone synthase gene cytochrome P450 11B2 polymorphism is associated with coronary artery disease in Taiwan
*英文作者姓名列：	Chi-Hung Chou1,2, Kwo-Chang Ueng3, Shun-Fa Yang1,4, Hui-Ling Chiou5,6
*英文服務單位：	1Institute of Medicine, Chung Shan Medical University, 2Division of Cardiology, Department of Internal Medicine, Yuan-Sheng Hospital, Yuanlin Branch, Yuanlin, 3Department of Internal Medicine, Chung Shan Medical University Hospital, 4Clinical Research Center, Department of Medical Research, Chung Shan Medical University Hospital, 5Department of Clinical Laboratory, Chung Shan Medical University Hospital, 6School of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung, Taiwan
* 投稿摘要：	The aldosterone synthase gene, cytochrome P450 11B2 (CYP11B2), and mineralocorticoid receptor (MR) genes have been reported to be associated with coronary artery disease (CAD). In this study, we investigated the association of single nucleotide polymorphisms (SNPs) of CYP11B2 (CYP11B2 T-344C) and MR (MR C3514G and MR C4582A) with CAD in Taiwanese. Six hundred and nine unrelated male and female subjects who received elective coronary angiography were recruited from Chung Shan Medical University Hospital. The enrolled subjects were those who had a positive noninvasive test. CYP11B2 T-344C, MR C3514G and MR C4582A were determined by polymerase chain reaction-restriction fragment length polymorphism. We found that women with CYP11B2 C/C had a higher risk of developing CAD. However, there were no significant differences in the genotype distributions of MR C3514G and MR C4582A between the women with and without CAD. In multivariate analysis, CYP11B2 T-344C was most significantly associated with CAD in Taiwanese women. In conclusions, CYP11CB2 C/C was more significantly associated with the development of CAD than diabetes mellitus or hypertension. This implies that CYP11CB2 C/C plays a more important role than some conventional risk factors in the development of CAD in Taiwanese women.
*關鍵字1 ：	CYP11B2
*關鍵字2 ：	coronary artery disease
*關鍵字3 ：	polymorphism
*關鍵字4 ：	mineralocorticoid receptor
*關鍵字5 ：	aldosterone synthase gene
* 服務機關：
* 第一作者：	周祈宏
* 身分字號：	*****85353
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審查委員意見：	不建議入選: comment: 受試者有病沒病及男女族群數目交代不清,結果之敘述令人疑惑
審查委員意見：	不OK
主任委員意見：	不同意