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歷 年 稿 件 內 容
 
*類別: D組-分子醫學
* 姓名: 楊順發
投稿種類: 壁報
*中文投稿標題: 第四型纖維細胞生長因子其基因多型性與泌尿上皮癌之相關性探討
*中文作者姓名列: 廖育晴1,翁瑋駿2,3, 邱慧玲4,5, 楊順發1,2
*中文服務單位: 中山醫學大學醫學研究部臨床研究中心1,中山醫學大學醫學研究所2, 童綜合醫院泌尿外科3,中山醫學大學附設醫院檢驗科4,中山醫學大學醫學檢驗暨生物技術學系5,台中,台灣
*英文投稿標題: Polymorphic variants of FGFR-4 associated with clinical characteristics in urothelial cell carcinoma
*英文作者姓名列: Yu-Ching Liaw1, Wei-Chun Weng2,3, Hui-Ling Chiou4,5, Shun-Fa Yang1,2
*英文服務單位: 1Clinical Research Center, Department of Medical Research, Chung Shan Medical University Hospital, 2Institute of Medicine, Chung Shan Medical University, 3Division of Urology, Department of Surgery, Tungs Taichung MetroHarbor Hospital, 4Department of Clinical Laboratory, Chung Shan Medical University Hospital, 5School of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung, Taiwan
* 投稿摘要: Fibroblast growth factor receptor-4 (FGFR-4) polymorphic variants have an important role on tumor development of various cancers. However, the association between FGFR-4 polymorphic variants and the risk of urothelial cell carcinoma (UCC) has not been determined. In this study, we studied the associations of FGFR-4 polymorphic variants with UCC susceptibility and its clinicopathological features. Four SNPs in FGFR-4 were analyzed among 558 participants comprising 279 controls and 279 patients with UCC by performing a real-time genotype PCR assay. Our results showed that UCC patients who carried at least one A genotype at rs1966265 exhibited a higher risk of invasive tumor stage compared with those carrying the wild-type genotype (p<0.05). Patients with UCC who carried at least one G genotype (AG and GG) at rs2011077 also exhibited a higher risk of invasive tumor stage. In conclusion, our findings suggest that polymorphic variants in FGFR-4 rs1966265 and rs2011077 may be associated with the risk of invasive tumor stage in Taiwanese patients with UCC. This is the first study to determine the association between FGFR-4 polymorphic variants and UCC tumor stage progression.
*關鍵字1 : FGFR-4
*關鍵字2 : polymorphic variants
*關鍵字3 : urothelial cell carcinoma
*關鍵字4 : susceptibility
*關鍵字5 : tumor stage
* 服務機關:
* 第一作者: 廖育晴
* 身分字號: *****88877
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審查委員意見: 建議入選
審查委員意見: OK
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