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歷 年 稿 件 內 容
 
*類別: F組-其他
* 姓名: 林銘祥
投稿種類: 壁報
*中文投稿標題: 探討蓮蓬萃取物對於乙醯胺基苯酚所誘導小鼠肝損傷之護肝研究
*中文作者姓名列: 林銘祥1、林慧萱1,2、黃筱尹3、徐成金3、李名世1,2、陳璟賢3#
*中文服務單位: 中山醫學大學附設醫院檢驗科1,,中山醫學大學醫學檢驗暨生物技術學系2,中山醫學大學營養系3, 台中
*英文投稿標題: In vivo hepatoprotective effect of lotus seedpod extract against acetaminophen-induced liver injury
*英文作者姓名列: Ming Hsiang Lin1; Hui-Hsuan Lin1,2; Hsiao-Yin Huang3; Cheng-Chin Hsu3; Ming-Shih Lee; Jing-Hsien Chen3#
*英文服務單位: 1 Clinical Laboratory, Chung Shan Medical University, Taichung, Taiwan
* 投稿摘要: Lotus seedpod extract (LSE), rich in polyphenol, has been shown to possess antioxidant, radioprotective, and anticancer activities, but there were no significant reports on its mechanism of hepatoprotective action. In this study, we have evaluated the hepatoprotective effect of LSE against acetaminophen (APAP) induced-liver injury in vivo. The BALB/c mice were supplemented with or without LSE (1% and 2%) during the 8-week treatment period in the presence or absence of APAP (i.p.; 400 mg/kg) twice per week. Our investigation showed that LSE treatments significantly decreased the serum levels of the hepatic enzyme markers GOT and GPT, and triglyceride induced by APAP. LSE also inhibited the formation of lipid peroxidative products and the serum levels of inflammatory cytokines (TNF-α, IL-1β and IL-6) during APAP treatment. 1% of LSE significantly restored the decrease in glutathione (GSH) content and elevated the level of antioxidant enzyme, catalase, in the liver. These results demonstrated that LSE will be useful for clinical implications in the prevention of liver injury and apply as healthy foods
*關鍵字1 : Lotus
*關鍵字2 : Lotus seedpod extract
*關鍵字3 : acetaminophen
*關鍵字4 : liver injury
*關鍵字5 : inflammatory antioxidant
* 服務機關:
* 第一作者: 林銘祥
* 身分字號: *****29682
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