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歷年稿件內容

*類別：	B組-微生物、病毒
* 姓名：	陳柏州
投稿種類：	壁報
*中文投稿標題：	亞胺培南誘導性鮑氏不動桿菌毒力分析
*中文作者姓名列：	陳柏州1; 梁睿辰2; 鄭明芳1; 林等義3; 張凱誌23
*中文服務單位：	國軍花蓮總醫院1;佛教慈濟大學醫學生物技術研究所2; 佛教慈濟醫院花蓮總院3
*英文投稿標題：	Virulence analysis of the inducible imipenem-resistant in Acinetobactor baumannii
*英文作者姓名列：	Po-Jo Chen1, Ruei-Chen Liang2, Ming-Fang Cheng1, Teng-Yi Lin3, Kai-Chih Chang2, 3
*英文服務單位：	HAFGH 1 ; TCU 2 ; TCH,Hualien 3
* 投稿摘要：	Over the last few decades, multidrug-resistant (MDR) A. baumannii has gradually emerged as an important nosocomial pathogen worldwide. Carbapenems, primarily, imipenem and meropenem, have been used to treat MDR A. baumannii infections. Recently, there are increasing reports of carbapenem-resistant A. baumannii being isolated. However, little is known about the effects that acquisition of imipenem resisitance on the virulence and fitness of A. baumannii. In order to assess the fitness and virulence impacts of imipenem resistance, an imipenem selected mutants was generated from imipenem susceptible strain ATCC 17978 by multistep selection resistance. A. baumannii ATCC 17978 and its induced imipenem-resistant derivatives, were analyzed for in vitro growth rate, detergent-serum resistance, biofilm formation and live-dead fluorescence microscopy assay. The in vitro growth rate of the imipenem-resistant mutant was similar to wild type strain. Detergent-serum resistance assays showed that the induced imipenem-resistant A. baumannii with increased resistance to detergent and serum. Biofilm formation assay showed that the imipenem-resistant mutant produced significantly more biofilm than the wild type strain. Furthermore, the live-dead assay result showed the induced imipenem-resistant A. baumannii exhibited higher toxicity to A549 cells than wild type. Based on these results, we show that there is significant impact on fitness and virulence after acquisition of imipenem resistance. We hope this research would be the basis of eliminating drug-resistant strains, and promote the further development of new antimicrobial agents in the future.
*關鍵字1 ：	Virulence factor
*關鍵字2 ：	Imipenem
*關鍵字3 ：	Imipenem-resistant
*關鍵字4 ：	Acinetobactor baumannii
*關鍵字5 ：	MDR
* 服務機關：
* 第一作者：	陳柏州
* 身分字號：	*****19080
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審查委員意見：	結果都用敘述確實驗數據佐證
審查委員意見：	不OK
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