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歷 年 稿 件 內 容
 
*類別： C組-生化、血清免疫
* 姓名： 曾碧緣
投稿種類： 壁報
*中文投稿標題： 以FIP-fve治療急慢性氣喘動物模型的信號傳導路徑
*中文作者姓名列： 曾碧緣
*中文服務單位： 中山醫學大學附設醫院檢驗科
*英文投稿標題： The effect of signal transduction after FIP-fve treatment in animal model of acute/chronic asthma
*英文作者姓名列： Tseng Pi-Yuan
*英文服務單位： Chung Shan Medical University Hospital
* 投稿摘要： As we known today, asthma is a repeated chronic inflammatory disease. It is characterized by a complex response of pulmonary eosinophilia, edema, mucus hypersecretion, and airway hyperreactivity (AHR). Under the condition of long term asthma, airway remodeling may develop by increased goblet cells, subepithelial fibrosis, airway smooth muscle mass increased and vascular hyperplasia. These make asthma control more difficult. According to recent research about asthma, leukotriene got important role in whole pathologic change of asthma. In this experiment, we evaluate the effect of FIP-fve on Th17 and Th22 and further evaluate the molecule environment and signal transduction of FIP-fve and montelukast on asthma treatment. Female BALB/c mice, after intraperitoneal ovalbumin sensitization on Days 0 and 14, received intranasal OVA on Days14 and Days 25-27. The sensitized mice were divided into different group according to the course of designed airway change. Different groups of sensitized mice received FIP-fve, Montelukast (leukotriene receptor antagonist) or combination or corticosteroid via intragastric feeding on Day 0-14. The other groups of sensitized mice received same drugs on Day 14-27. Moreover, the chronic stage in this asthma animal model was received intranasal OVA on Days 69-73 and the model was set up. According to our result, we found that Fungal immunomodulatory peptide-fve (FIP-fve) could suppress AHR response, induced Th1, Th22 and Treg cytokine, and reduced Th2 cytokine (such as IL4, IL5 and IL13), Th17 cytokine, and FIP-fve could reduce collagen precipitation. So we suggest that oral FIP-fve had an anti-inflammatory effect on OVA-induced airway inflammations and might posses the potential for alternative therapy for allergic airway diseases.
*關鍵字1 ： FIP-fve
*關鍵字2 ： asthma
*關鍵字3 ： AHR
*關鍵字4 ： allergen
*關鍵字5 ： cytokine
* 服務機關：
* 第一作者： 曾碧緣
* 身分字號： *****48746
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