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歷 年 稿 件 內 容
 
*類別： C組-生化、血清免疫
* 姓名： 張懿欣
投稿種類：
*中文投稿標題： 第四型介白素促進肌肉細胞分化作用並加強胰島素功效
*中文作者姓名列： 張懿欣1、陳姿伶1、何國鼎1、鄭欣怡1、楊境評1、蕭明裕2
*中文服務單位： 1弘光科技大學、2國立陽明大學
*英文投稿標題： Interleukin-4 Promotes Myogenesis and Improves Myocyte Glucose Uptake by Boosting Insulin Efficacy
*英文作者姓名列： Yih-Hsin Chang1, Tzu-Lin Chen1, Kuo-Ting Ho1, Hsin-Yi Cheng1, Ching-Ping Yang1, and Ming-Yuh Shiau2
*英文服務單位： 1Department of Biotechnology and Laboratory Science in Medicine, National Yang-Ming University, Taipei, 2Department of Nursing, College of Medicine & Nursing, Hungkuang University, Taichung, Taiwan
* 投稿摘要： We previously report the anti-inflammatory cytokine interleukin-4 (IL-4) promotes glucose tolerance and insulin sensitivity. The effects of IL-4 on energy metabolism in muscle, the largest insulin-targeting organ, remain obscure. Therefore, it is tempting for us to explore the roles of IL-4 in energy metabolism of muscle cells. Effects of IL-4 on myogenesis and the potential interaction between IL-4 and insulin in regulating glucose metabolism of C2C12 myoblasts and terminal differentiated myocytes were analyzed. In addition, the influences of IL-4 to Akt and GSK-3β in muscle cells under diabetic or insulin resistant condition were also examined in vivo. IL-4 promoted myogenesis by up-regulating mature myocyte-specific markers, including muscle-restricted coiled-coil protein, myogenin and myosin heavy chain. IL-4 enhanced glucose metabolism by boosting insulin signaling through autocrine and/or paracrine mechanisms. In insulin-resistant diabetic mice, transient and long-term IL-4 showed differential effects on insulin signaling molecules and efficacy. However, long-term IL-4 was insufficient to ameliorate insulin resistance probably due to physical adaptation under consistent IL-4 exposure for meeting the in vivo energy demands to maintain homeostasis. In summary, IL-4 promotes myogenesis and improves glucose metabolic efficacy in muscle cells under physiological insulin-sensitive condition. Nevertheless, once insulin resistance is developed, it takes dominant role to deviate cellular responses to stimuli.
*關鍵字1 ： interleukin-4
*關鍵字2 ： myogenesis
*關鍵字3 ： insulin
*關鍵字4 ： glucose uptake
*關鍵字5 ： myocytes
* 服務機關：
* 第一作者： 張懿欣
* 身分字號： *****46287
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