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歷 年 稿 件 內 容
 
*類別： A組-鏡檢、血液、血庫
* 姓名： 劉玥彤
投稿種類：
*中文投稿標題： 調查醫院血庫具擬C抗體特異性之自體抗體
*中文作者姓名列： 劉玥彤, 張文秋, 王雅惠, 蔡弘文
*中文服務單位： 國立成功大學附設醫院病理部
*英文投稿標題： Investigation of Autoantibodies with Mimicking Anti-C Specificity in a Hospital-Based Blood Bank
*英文作者姓名列： Yueh-Tung Liu, Wen-Chiu Chang, Yea-Hu Wang, Hung-Wen Tasi
*英文服務單位： Blood Bank, Department of Pathology National Cheng Kung University Hospital
* 投稿摘要： Background: Mimicking antibody, showing specificity most often to the Rh system antigens, are generally considered “not common” in a routine blood bank practice. Mimicking antibody had been reported to cause clinically significant autoimmune hemolytic anemia (AIHA). The aim of this study was to investigate the frequency of auto-antibodies with mimicking specificity which should be discriminated from true allo-antibodies for optimal transfusion practices. Methods and Materials: From 2013 to 2015, the clinically significant red cell antibodies was identified using manual polybrene (MP) method and polyethylene glycol indirect anti-globulin test (PEG-IAT). Serum samples that were suspected to have mimicking antibodies were adsorbed and their specificity was determined. Additionally, RBC samples from these patients were investigated by direct anti-globulin test (DAT) with anti-immunoglobulin (Ig) G or anti-C3d antibodies. Results: From 2013 to 2015, the clinically significant red cell antibodies were identified in 1922 patients using MP method and PEG-IAT. Anti-C antibodies were detected in 62 patients. The C antigen phenotype of these patients was determined. Among them, 56 (90.3%) cases were found to be allo-antibodies and 6 (9.7%) were auto-antibodies with mim¬icking anti-C specificity which were confirmed by the adsorption method. Finally, DAT showed that four of the mimicking auto-antibodies were IgG isotype. Conclusions: We identified that 9.7% of anti-C antibodies were mimicking auto-antibodies with apparent C-antigen specificity. The clinical significance of the mimicking auto-antibodies should be further investigated.
*關鍵字1 ： Mimicking specificity
*關鍵字2 ： Autoantibodies
*關鍵字3 ： Anti-C antibodies
*關鍵字4 ： IgG isotype
*關鍵字5 ： Blood Bank
* 服務機關：
* 第一作者： 劉玥彤
* 身分字號： *****65216
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