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歷 年 稿 件 內 容
 
*類別: D組-分子醫學
* 姓名: 呂旭峰
投稿種類: 壁報
*中文投稿標題: 哇巴因透過抑制基質金屬蛋白酵素導致人類骨肉瘤細胞株(U-2 OS)無法侵襲與轉移
*中文作者姓名列: 莊淑華1、李慶孝2、呂旭峰1、鍾景光3
*中文服務單位: 振興醫療財團法人振興醫院1,仁德醫護管理專科學校2,中國醫藥大學生物技術學院3
*英文投稿標題: Ouabain Inhibits the migration and invasion of U-2 OS human osteosarcoma cells through suppressing of matrix metalloproteinase
*英文作者姓名列: Juang Shu-Hua1; Lee Ching Hsiao2; Lu Hsu-Feng1; Chung Jing-Gung3
*英文服務單位: 1Department of Clinical Pathology, Cheng Hsin General Hospital, Taipei;2Jen-The Junior College of Medicine, Nursing and Management, Miaoli County, Taiwan; 3Department of Biological Science and Technology, China Medical University, Taichung, Taiwan, R.O.C.
* 投稿摘要: Human osteosarcoma is the most common primary bone tumor. Ouabain can be found in many organ of Acokanthera schimperi and Strophanthus gratus plants and has been reported that ouabain has anticancer activities on many human cancer cells. There is no report to show that the anticancer effects of ouabain in human osteosarcoma cells. In the present study, we investigated the anti-metastasis effects of ouabain in human osteosarcoma (U-2 OS) cells. U-2 OS cells were treated with various concentration of ouabain and then to investigate the anti-metastasis effects in vitro. In our data, we found that ouabain decreased the secretion of matrix metalloproteinase (MMP-2) and inhibited the ability of migration and invasion. These results indicated that ouabain suppress metastasis in U-2 OS cells. Finally, we suggest that ouabain may have a potential to be an anti-metastasis agent on human osteosacoma cells (U-2 OS) in the future.
*關鍵字1 : human osteosarcoma
*關鍵字2 : Ouabain
*關鍵字3 : matrix metalloproteinase
*關鍵字4 : migration
*關鍵字5 : invasion
* 服務機關:
* 第一作者: 莊淑華
* 身分字號: *****85542
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審查委員意見: 不OK
審查委員意見: 缺乏具體的數據呈現研究結果
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