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歷 年 稿 件 內 容
 
*類別： F組-其他
* 姓名： 林雲冰
投稿種類： 壁報
*中文投稿標題： 抗癲癇藥品與肝癌之相關性-病例對照研究
*中文作者姓名列： 林雲冰、林橙莉、林明佳、洪東榮、高嘉鴻
*中文服務單位： 中國醫藥大學藥學系、中國醫藥大學附設醫院毒物科
*英文投稿標題： Association between Antiepileptic Drugs and Hepatocellular Carcinoma in Epilepsy Patients: A Population-Based Case-Control Study
*英文作者姓名列： Yun-Ping Lim, Cheng-Li Lin, Ming-Chia Lin, Dong-Zong Hung, Chia-Hung Kao
*英文服務單位： Department of Pharmacy, College of Pharmacy, China Medical University, Taichung. Department of Emergency, Toxicology Center, China Medical University Hospital, Taichung, Taiwan.
* 投稿摘要： Abstract Objective: To explore any association between antiepileptic drugs (AEDs) use and the risk of developing hepatocellular carcinoma (HCC). Methods: The case group comprised 1454 epilepsy patients with newly diagnosed HCC, and the control group comprised 1448 epilepsy patients without HCC. Both groups had similar distributions of sex and age, and follow-up duration. Possible associations with the AEDs in Taiwan, including barbiturates, benzodiazepines, hydantoins, and other antiepileptics were examined. Results: In the statistical analysis, after adjusted for AEDs (phenobarbital and primidone, clonazepam, clorazepate and diazepam, and other AEDs), and for the comorbidities of diabetes, chronic liver disease and cirrhosis, hepatitis B and C virus infection, and alcoholism, the odds ratio (OR) of HCC was 1.22 (95% confidence interval [CI]: 1.01–1.47) for the group of phenytoin users compared with non-phenytoin users. An annual mean 5 of defined daily doses (DDDs) of phenytoin (OR: 0.58, 95% CI: 0.46–0.74) was inversely correlated with the risk of HCC. However, with an annual mean >180 DDDs, phenytoin use was significantly associated with an increased risk of HCC (OR: 14.5, 95% CI: 7.85–26.8). In addition, compared with non-phenytoin users, HCC patients who had used phenytoin within 1 year of HCC diagnosis were at a greatest risk of developing HCC (adjusted OR: 2.29, 95% CI: 1.71–3.08), followed by those who had used phenytoin within 2 years of diagnosis (adjusted OR: 1.92, 95% CI: 1.44–2.56). Significance: The results indicate that high-dose phenytoin was associated with a statistically significant increased odds ratio for HCC, which was not demonstrated for low-dose phenytoin.
*關鍵字1 ： Epilepsy
*關鍵字2 ： antiepileptic drugs (AEDs)
*關鍵字3 ： hepatocellular carcinoma (HCC)
*關鍵字4 ： population-based
*關鍵字5 ： case-control study
* 服務機關：
* 第一作者： 林雲冰
* 身分字號： *****40388
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