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歷 年 稿 件 內 容
 
*類別： D組-分子醫學
* 姓名： 陳香蘭
投稿種類： 壁報
*中文投稿標題： DNA修補基因hOGG1多型性與子宮內膜癌之相關性研究
*中文作者姓名列： 陳香蘭1*、鄧秀珍2*、鄭伊涵2、郭廷妤2、陳琮棋2、黃慶三3、唐光生2#、池宇佳2#
*中文服務單位： 高雄市立凱旋醫院檢驗科1,輔英科技大學醫學檢驗生物技術系2,國泰綜合醫院檢驗科3
*英文投稿標題： Association of the DNA Repair Gene hOGG1 Polymorphisms with Endometrial Cancer
*英文作者姓名列： Chen Hsiang-Lan1*; Teng Hsiu-Chen2*;Cheng I-Han2;Guo Ting-yu2;Chen Chung-Chi2 ;Huang Ching-Shan3 ;Tang Kung-Sheng2# ; Chih Yu-Chia2# ;
*英文服務單位： Department of Laboratory Kaohsiung Municipal of Kai-Syuan Psychiatric Hospital1,Department of Medical Laboratory Science and Biotecnology Fooyin University2, Department of Laboratory Medicine Cathay General Hospital3
* 投稿摘要： The DNA repair enzyme hOGG1 is a DNA glycosylase or AP lyase that has been hypothesized to play an important role in preventing carcinogenesis by repairing oxidative damage to DNA . Specifically, glycosylase or AP lyase can efficiently repair 8-OH-G a major base lesion produced by ROS, formed as a byproduct of endogenous metabolism or exposure to environmental oxidizing agents, such as ionizing radiation or chemical genotoxic compounds. 8-OH-G is highly mutagenic and, if not excised on DNA replication, can cause GC to TA transversions, which occur frequently in several oncogenes and tumor suppressor genes.Ser326Cys polymorphism in the hOGG1 gene is involved in the repair of 8-hydroxyguanine in oxidatively damaged DNA. In this study, hOGG1 genotyping was performed by PCR-restriction fragment length polymorphism analysis of genomic DNA isolated from 97 Taiwanese endometrial cancer cases and 345 individual healthy donors . We found that the frequency of hOGG1 Ser-Ser, Ser-Cys, and Cys-Cys genotypes were 19.6, 47.4, and 33.0% in endometrial cancer, and 18.6, 46.9, and 34.5% in the controls. (p＞0.05) . No statistically significant associations between the genotypes and endometrial cancer were observed. These results suggest that the hOGG1 Ser326Cys polymorphism is not a major genetic risk factor for endometrial cancer.
*關鍵字1 ： DNA glycosylase
*關鍵字2 ： carcinogenesis
*關鍵字3 ： endogenous metabolism
*關鍵字4 ： genotoxic compounds
*關鍵字5 ： polymorphism
* 服務機關：
* 第一作者： 陳香蘭
* 身分字號： *****18108
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