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歷 年 稿 件 內 容
 
*類別: D組-分子醫學
* 姓名: 陳香蘭
投稿種類: 壁報
*中文投稿標題: MDR1基因C1236T多型性與慢性骨髓性白血病之相關性研究
*中文作者姓名列: 陳香蘭1*、唐顥軒2*、簡大智3、洪憲程3、陳琮棋3、鄧秀珍3、黃慶三4、唐光生3#、池宇佳3#
*中文服務單位: 高雄市立凱旋醫院檢驗科1,大仁科技大學藥學系2,輔英科技大學醫學檢驗生物技術系3,國泰綜合醫院檢驗科4
*英文投稿標題: Association of C1236T Polymorphisms of Multidrug Resistance 1(MDR1) Gene with Chronic Myeloid Leukemia (CML)
*英文作者姓名列: Chen Hsiang-Lan1*;Tang Hao-Hsuan2* ;Jian Da-Jhih3 ;Hong Sian -Cheng 3 ;Teng Hsiu-Chen2;Chen Chung-Chi3;Huang Ching-Shan4 ;Tang Kung-Sheng3# ;Chih Yu-Chia3# ;
*英文服務單位: Department of Laboratory Kaohsiung Municipal of Kai-Syuan Psychiatric Hospital1,Department of Pharmacy Tajen University2,Department of Medical Laboratory Science and Biotecnology Fooyin University3,Department of Laboratory Medicine Cathay General Hospital4 ,
* 投稿摘要: The P-glycoprotein, a product of multiple drug resistance 1 (MDR1) gene, is a membrane efflux pump localized in epithelial cells in the small and large intestine, a part of the gastrointestinal barrier that protects cells against xenobiotics from our diet, bacterial toxins, drugs and other biologically active compounds, possibly carcinogens. The study population consisted of 78 subjects with chronic myeloid leukemia and 227 healthy controls. The C1236T MDR1 gene polymorphisms was identified using the polymerase chain reaction- restriction fragment length polymorphism method. We found that distribution of MDR1 genotype among controls (CC, 12.8%; CT, 50.2%; and TT 37.0%) was not significantly different from that among chronic myeloid leukemia cases (11.5%, 51.3% and 37.2%, respectively) (P > 0.05). These results suggest that C1236T polymorphisms of multidrug resistance 1(MDR1) gene might not have potential as a genetic marker for chronic myeloid leukemia susceptibility.
*關鍵字1 : P-glycoprotein
*關鍵字2 : multiple drug resistance 1
*關鍵字3 : gastrointestinal barrier
*關鍵字4 : xenobiotics
*關鍵字5 : susceptibility.
* 服務機關:
* 第一作者: 陳香蘭
* 身分字號: *****18108
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審查委員意見: OK
審查委員意見: 沒有特殊的研究發現
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