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歷 年 稿 件 內 容
 
*類別：
* 姓名： 徐文通
投稿種類： 口頭
*中文投稿標題： Investigate the Renal Function of Type 2 Diabetes Mellitus Patients
*中文作者姓名列：
*中文服務單位：
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* 投稿摘要： Background：In addition to acute and chronic kidney damage, hypertension and diabetes are the important factor in end stage renal disease (ESRD), especially the diabetes. End stage renal disease and diabetes are the major social and medical causes of the significant financial burden. To make a good glycemic control and regular screening of renal function in diabetic patients are the most important work to prevent ESRD. This cross-sectional study targeted in patients with diabetes and focus on the correlation between blood glucose and renal function. We wish the final result can offer us the way to reduce the incidence of end stage renal disease. Materials and methods: Patients are recognized by the metabolic specialist and filled with informed consent, 84 diabetic patients and 37 non-diabetic patients. The samples of urine and serum were tested with Siemens Clinitek Status Urine Analyzer and Roche for the determination of biochemical analyzer C501. To compare and determine the difference degree of data with t test. Results: In diabetic patients, the stage of urine albumin/ creatinine excretion ratio (ACR) (1o Low ACR = 9.7、2o Mid ACR = 101.3、3o High ACR = 1352.4) increased with the mean blood sugar level （1 o=121、2 o= 156、3 o= 145 mg/dL) and showed a significant difference（P<0.01）than non-diabetic patients（Glu.=87 mg/dL)。The glycated hemoglobin (HbA1c) concentrations（1 o=7.0、2 o= 7.7、3 o= 7.8 %) also increased with the stage of ACR and showed a significant differences（P<0.01）with the control group was also found. The cystatin C concentration also increased with stage of ACR（1 o=1.00、2 o= 1.25、3 o= 1.31 mg/L) and showed significant differences with non-diabetic patients（Cys C=0.67 mg/L). Conclusion：With the increase of ACR, cystatin C, glucose and HbA1c concentrations were subsequently increased, and showed significant differences with the control group. After all, a close relation exist between the blood glucose levels and renal function, and it seems to be that intensive diabetes blood sugar control can slow down the decline of renal function. 敬覆評審意見如下： １、此研究係以本院新陳代謝科醫師認可之評估工具 ACR 評估實驗族群之腎功能，為增加可信度(避免因年齡、性別與人種等因素影響)再增加Cystatin C (參考值Male: 0.57 - 0.96，Female: 0.50 - 0.96 mg/L) 數據佐證。 ２、血糖的控制與腎功能之對應關係已然明確，個人謹以檢驗角度及數據驗證方式做拋磚引玉之舉，若有失當之處還請委員指點為是！謝謝。
*關鍵字1 ： Cystatin C
*關鍵字2 ： HbA1c
*關鍵字3 ： ACR (urine albumin / creatinine ratio)
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* 服務機關：
* 第一作者： 徐文通
* 身分字號： *****46482
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 開啟檔案
審查委員意見： ok
審查委員意見： １、應補述以何種數據評估實驗族群腎功能？２、血糖的控制與腎功能之對應關係以非常明確，此文並無做新的闡述。
主任委員意見： ok
 
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