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歷 年 稿 件 內 容
 
*類別：
* 姓名： 姜泰安
投稿種類： 壁報
*中文投稿標題： Bromelain regulation cytokines in the mechanism of inhibition of fibrosis in pulmonary fibrosis
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*英文投稿標題：
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* 投稿摘要： Pneumonia in the course of the disease will develop into pulmonary fibrosis. The current study found that bromelain has many effects, including anti-inflammatory effect. However, no studies have pointed out that the effect of bromelain to inhibit pulmonary fibrosis.Many studies have demonstrated that dysregulation of growth factors might be the maincauses underlying the mechanism of Pulmonary fibrosis.The present study found that bromelain has anti-inflammatory effect.However, no studies have pointed out that the effect of bromelain to inhibit pulmonary fibrosis. Therefore, we studied the role of bromelain in A549 (human alveolar epithelial cells). However, transforming growth factor (TGF)-β1 is a multifunctional cytokine which also plays an important role in progressive lung fibrosis. Therefore, in this study , we use transforming growth factor (TGF)-β1 stimulation human alveolar epithelial cells (A549) were cultured in vitro, to simulation of lung fibrosis. We use ELISA in the bromelain (1,5,10,20,25 μl / ml) dose, cell viability of A549 cells in appropriate doses rise, but at high concentrations, survival wasthere are lower.We added TGF-β1 stimulation before adding the pineapple enzymes to explore the change of the caspase protein and found that caspase-3, caspase-7, caspase-9, PARP expression alone by adding TGF-β1 significantly increased by adding bromelain significantly reduced. These results suggest that the protective efficacy of bromelain for pulmonary fibrosis.
*關鍵字1 ： bromelain
*關鍵字2 ： pulmonary fibrosis
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* 第一作者： 姜泰安
* 身分字號： *****60805
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