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歷 年 稿 件 內 容
 
*類別：
* 姓名： 楊淑淩
投稿種類： 壁報
*中文投稿標題： Falsely Elevated Plasma Protein C Activity Level in a Severely Ill Pregnant Woman after Fibrinolytic
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* 投稿摘要： Case report: A 31-year-old pregnant woman was referred to the emergency room for sudden onset of chest pain for 14 hours prior to admission. Cardiopulmonary resuscitation (CPR) was performed for cardiac arrest happening later. After CPR, continuous venous-venous hemodialysis (CVVH), extracorporeal membrane oxygenation (ECMO) and Tissue plasminogen activator (tPA) pump were used to maintain the patient’s vital signs. Besides, an emergent percutaneous coronary intervention (PCI) was conducted for thrombolytic therapy. The coagulation profile thereafter showed prolonged APTT (>240 sec), prolonged PT (>160 sec.), severe hypofibrinogenemia (36.2 mg/dL) and increased D-dimer concentration (9,398 ng/mL FEU). The thrombophilia profile showed decreased levels of antithrombin function (26.4%), protein S activity (0.2%), free protein S antigen (5.9%) and protein C antigen (27.5%, enzyme-linked fluorescent immunoassay, VIDAS, bioMerieux, France), whereas Protein C function (71.4%, Chromogenic HemosIL Protein C kit, ACL TOP, IL, Italy) was within normal limits that was not consistent with a low protein C amount as measured. Because plasma heparin concentration measured by anti-Xa assay was 0.46 IU/mL, heparin interference with Protein C functional assay was ruled out. The substrate blank activity of the patient sample was shown to be 34.8% as determined by testing without adding substrate in the procedure. Therefore, the presumed protein C activity after subtraction of blank activity was 36.6%, indicating an overestimation of protein C activity due to sample interference probably resulting from fibrinolytic therapy. Conclusion: To avoid the subsequent risk of overestimating the protein C function, a substrate blank activity is recommended to measure and correct of the results.
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* 第一作者： 楊淑淩
* 身分字號： *****01511
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