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歷 年 稿 件 內 容
 
*類別:
* 姓名: 呂旭峰
投稿種類: 壁報
*中文投稿標題: 二烯丙基三硫化物誘發人類體外血癌WEHI-3細胞株之凋零並改變正常與血癌小鼠的免疫反應
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* 投稿摘要: Diallyl trisulfide (DATS), a promising cancer chemo-preventive constituent of garlic, has been shown to against cultured many types of human cancer cells correlates with cell cycle arrest and induction of apoptosis, but the fate of the cells arrested and immune responses in leukemic mice remains elusive. Herein, we investigated the effects of DATS on growth inhibition of murine leukemia WEHI-3 cells in vitro and used WEHI-3 cells to generate leukemic mice in vivo, following to investigate the effects of DATS in animal model. In vitro studies, we found that DATS induced cell death of WEHI-3 cells through the G0/G1 phase arrest and induction of apoptosis through the caspase-3 activation. In vivo studies, we found that DATS decreased the weight of spleen of leukemia mice but did not affect the spleen weight of normal mice. DATS promoted the immune responses such as promoted the macrophage phagocytosis and NK cell activities in WEHI-3 leukemic and normal mice, however, only promotes NK cell activities in normal mice. DATS increases the levels of CH11b (monocytes) and macrophage (Mac-3) in leukemia mice but only promoted CD3 (T cells) in normal mice. In conclusion, the results of the present study indicate that DATS induced cell death via induction of apoptosis in mice leukemia WHEI-3 cells. DATS promotes immune responses in leukemia and normal mice.
*關鍵字1 : Diallyl trisulfide
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* 第一作者: 呂旭峰
* 身分字號: *****35042
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