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*類別：
* 姓名： 呂旭峰
投稿種類： 壁報
*中文投稿標題： Histopathology Analysis in Toxicological Assessment of Agaricus blazei Murill and Antrodia Cinnamome
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* 投稿摘要： This study was conducted to assess the safety and tolerability of Agaricus blazei Murrill (ABM) and Antrodia cinnamomea (AC) in general pathological studies. Male mice were randomized and allocated into control (group 1) and experimental (second to fourth groups) groups of ten animals each. Groups 2, 3 and 4 were orally administered high (10 mg/0.2 ml), medium (5 mg/0.2 ml) and low (0.1 mg/0.2 ml) doses of Agaricus blazei Murill daily for 28 days. Female mice were also randomized and allocated similarly into groups of ten animals each. The same allocations were also performed by the treatment of Antrodia cinnamomea with high (1666.67 mg/kg/day), medium (833.3 mg/kg/day) and low (16.67 mg/kg/day) doses. Experimental groups were orally administered the three different dose levels daily. Negative controls were fed with distilled water. At the end of the study, histopathological examinations were performed for the kidney, liver, spleen and so on. Nonsignificant hepatocellular necrosis in centrilobular regions, without any signs of vascular or inflammatory changes was found. The spleen did not show any significant loss of volume, and nor was any splenic hyperplasia seen. ABM did not induce any vascular or inflammatory changes, or signs of vascular congestion, tubular necrosis or glomerular atrophy, which is a degenerative phenomenon. In summary, based on our findings, no infiltration, aggregation, necrosis and atrophy were found in control and experimental sections of liver, spleen and kidney.
*關鍵字1 ： Agaricus blazei Murrill
*關鍵字2 ： Antrodia cinnamomea
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* 第一作者： 呂旭峰
* 身分字號： *****35042
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