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歷 年 稿 件 內 容
 
*類別：
* 姓名： 謝明昌
投稿種類： 壁報
*中文投稿標題： Effects of metallothionein-1 genetic polymorphism and cigarette smoking on the development of hepato
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* 投稿摘要： The lower expression of metallothionein (MT) was observed in liver cancer tumor. Such phenomenon might be influenced by oxidative stress, thus resulting in the cells were more susceptible to DNA damage and apoptotic death. Especially, oxidative stress induced by cigarette smoking might affect the MT-1 expression. We designed a hospital-based case-control study to evaluate the effects of MT-1 genotypes and smoking on hepatocellular carcinoma (HCC) occurrence. A total of 102 HCC patients and 191 matched healthy controls were recruited, and epidemiological information was collected. Six genotypes of MT-1 were determined with TaqMan SNP Genotyping Assays. Individuals possessed MT-1 rs8052394 A, rs964372 G and rs8052334 T alleles as well as cigarette smoking had increased risks of HCC, respectively; and these alleles had higher linkage disequilibrium. Carriers with MT-1 rs8052394/rs964372/rs8052334 A-G-T haplotype had a 2.25-fold (95% confidence interval (CI): 1.46-3.26) risk for HCC development than reference group (A-C-T, the most common haplotype). Compared to nonsmokers with other haplotypes (A-C-T, G-G-C, A-G-C, G-G-T, G-C-T, and G-C-C), nonsmokers with A-G-T haplotype had a 1.93-fold (95% CI: 1.01-3.71) increased risk, and smokers with other haplotypes had a 3.66-fold (95% CI: 1.78-7.54) increased risk, whereas smokers carrying A-G-T haplotype had the highest risk (matched relative risk (RRm): 6.72; 95% CI: 2.86-15.79) of developing HCC. In conclusion, the MT-1 haplotypes and cigarette smoking were associated with HCC development.
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* 第一作者： 謝明昌
* 身分字號： *****24379
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