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*類別：
* 姓名： 楊順發
投稿種類： 壁報
*中文投稿標題： Single nucleotide polymorphisms and haplotypes of VEGF-C are associated with the incidence of oral s
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* 投稿摘要： Vascular endothelial growth factor (VEGF)-C, an angiogenic/lymphangiogenic factor with high expression levels in tumor tissues, plays important roles in the development of several malignancies. This study was designed to examine associations of five VEGF-C gene polymorphisms with the susceptibility to and clinicopathological characteristics of oral squamous cell carcinoma. Five single-nucleotide polymorphisms (SNPs) of VEGF-C were analyzed by a real-time polymerase chain reaction (PCR) in 489 patients with oral cancer and 520 healthy controls. In this study, we found that the VEGF-C rs2046463 and rs7664413 polymorphisms were associated with oral-cancer susceptibility but not with any clinicopathological parameters. The GGACA or GACTG haplotype of five VEGF-C SNPs (rs3775194, rs11947611, rs1485766, rs7664413, and rs2046463) combined was also related to the risk of oral cancer. Among 622 smokers, VEGF-C polymorphism carriers who also chewed betel quid were found to have a 10.5~20.6-fold risk of having oral cancer compared to the VEGF-C wild-type carrier who did not chew betel quid. Among 465 betel-quid chewers, VEGF-C polymorphism carriers who also smoked had a 2.8~14.1-fold risk of having oral cancer compared to those who carried the wild type but did not smoke. Our results suggest that the two SNPs of VEGF-C (rs2046463 and rs7664413) and either of two haplotypes of five SNPs combined have potential predictive significance in oral carcinogenesis. Gene-environmental interactions among VEGF-C polymorphisms, smoking, and betel-quid chewing might alter one's susceptibility to oral cancer.
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* 第一作者： 楊順發
* 身分字號： *****08094
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