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歷 年 稿 件 內 容
 
*類別:
* 姓名: 楊順發
投稿種類: 壁報
*中文投稿標題: Impact of monocyte chemoattractant protein-1 gene polymorphisms on coronary artery disease
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* 投稿摘要: Coronary artery disease (CAD) was the second leading cause of death in Taiwan. Smooth muscle cells, monocytes/macrophages, and endothelial cells produce monocyte chemoattractant protein-1 (MCP-1) within atherosclerotic plaques. Previous studies have well-documented the association between MCP-1 expression and susceptibility to, or clinicopathological features, of CAD. This study investigated the relationships between MCP-1 -2518A/G genetic polymorphisms and CAD in the Taiwanese population. A total of 608 subjects, including 392 non-CAD controls and 216 patients with CAD, were recruited and subjected to PCR-RFLP to evaluate the effects of the polymorphic variants on CAD. Results indicated a significant association between MCP-1 -2548 gene polymorphism and susceptibility to CAD. GG genotypes (OR=1.629; 95 % CI=1.003-2.644), or individuals with at least one G allele (OR=1.511; 95 % CI=1.006-2.270), had a higher risk of CAD as compared with AA genotypes. G allele in MCP-1 2518 might contribute to higher prevalence of atrial fibrillation in CAD patients (OR=4.254; p<0.005). MCP-1 -2518G gene polymorphism represents important factors in determining susceptibility to CAD, and the contribution of MCP-1 -2518G could be through effects on atrial fibrillation in CAD patients.
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* 第一作者: 李佩娟
* 身分字號: *****63126
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