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歷 年 稿 件 內 容
 
*類別:
* 姓名: 余文發
投稿種類: 壁報
*中文投稿標題: 細胞膽固醇對於彎曲桿菌感染誘導發炎反應的重要性
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* 投稿摘要: Campylobacter jejuni (C. jejuni) is one of the most important pathogen that induced gastrointestinal disease in the world. Consist with the clinical outcomes of intestinal epithelium inflammation by C. jejuni, which was thought to harbor the ability in the invasion of host cells. It has been reported that infection of C. jejuni requires invasins for efficient internalization of bacterium into host cells. In this study, direct sequence comparisons revealed that invasins amino acid sequence was similar to type III secretion system (TTSS), which was found to be required sufficient membrane cholesterol for its pathogenesis. Our data showed that the invasion activity was significantly decreased in invasins mutant strain when compared with wild-type C. jejuni. In addition, depletion of cholesterol reduces the association of invasins with lipid rafts. Our results revealed that cellular cholesterol plays a critical role in the infection of cells by C. jejuni. Investigation of bacterial secreted protein will lead to a better understanding of the pathogenic mechanisms associated with C. jejuni–induced enterocolitis.
*關鍵字1 : Campylobacter jujuni
*關鍵字2 : type III secretion system
*關鍵字3 : inflammation
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* 服務機關:
* 第一作者: 余文發
* 身分字號: *****91039
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審查委員意見: 無意見
審查委員意見: OK
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