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歷 年 稿 件 內 容
 
*類別:
* 姓名: 陳荷容
投稿種類: 壁報
*中文投稿標題: 開發治療口腔癌的chalcone合成類似物
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*中文服務單位:
*英文投稿標題:
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*英文服務單位:
* 投稿摘要: Oral cancer is one of the most prevalence cancers, which is the 6th leading cancer in Taiwan. Potent effects of surgical treatment are not as expected, it is urgent to develop an effective treatment for eradicating. A series of chalcone analogues have been found to inhibit nitric oxide production in LPS/IFN-γ-treated macrophages. In the present study, we assessed that whether chalcones have the biological activities in the inhibition of oral cancer. Our data showed that chalcone-15 is able to inhibit several oral squamous carcinoma cell lines, but has no effect on normal cells (gingival fibroblast cells). The molecular mechanism of chalcone-15 in the inhibition of oral cancer cells was arrested cell cycle at G2/M phase. Chalcone-15 caused a dose-dependent decrease in protein expression of anti-apoptotic protein Bcl-2, with concomitant increasing in pro-apoptotic protein Bax and Bak. The results from this study indicated that development of chalcone analogues might have multiple functions not only anti-inflammation but inhibit oral cancer cell proliferation.
*關鍵字1 : chalcone analogues
*關鍵字2 : oral squamous carcinoma cells
*關鍵字3 : apoptosis
*關鍵字4 :
*關鍵字5 :
* 服務機關:
* 第一作者: 陳荷容
* 身分字號: *****94059
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開啟檔案
審查委員意見: 建議題目修正為『治療口腔癌的chalcone合成類似物之開發』,建議英文應再檢視修正文法。
審查委員意見: OK
主任委員意見:
 
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