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*類別：
* 姓名： 趙恒立
投稿種類：
*中文投稿標題： 評估Sysmex XE-5000之reticulocyte hemoglobin equivalent與DF-Hypo XE index用於診斷血液透析病人缺鐵性貧血之可行性
*中文作者姓名列：
*中文服務單位：
*英文投稿標題：
*英文作者姓名列：
*英文服務單位：
* 投稿摘要： Anemia is a common complication of chronic kidney disease(CKD), particularly in dialysis patients. European guidelines stress that iron status should be regularly assessed for the optimal management of renal anemia. These indicate reticulocyte hemoglobin content (CHr) and the percentage of hypochromic RBC (%Hypo) as markers for functional iron deficiency. CHr equate with reticulocyte hemoglobin equivalent (Ret-He) which was measured on the Sysmex XE-5000. DF-Hypo XE obtained from calculation of haemoglobin, haematocrit and Ret-He, as a index equate with %Hypo. The aim of this study was to evaluate the clinical usefulness of Ret-He and DF-Hypo XE index as predictors of iron deficiency anemia (IDA) in haemodialysis patients. Patients and methods: In 375 blood samples from patients on chronic haemodialysis. Ret-He was compared with traditional parameters for iron deficiency (serum iron <40 ug/dl, Tsat <20%, serum ferritin <100 ng/ml, hemoglobin <11 g/dl) for identifying iron-deficient status. Biochemical parameters were measured on Hitachi 7180 and Ret-He were measured on the basis of automated fluorescent flow cytometry which in the reticulocyte channel, using a polymethine dye on a Sysmex XE-5000. Results: Overall dialysis patients, Ret-He and DF-Hypo XE index mean value was 35.2 pg and 5.2. Compared with IDA, mean value of 32.3 pg for Ret-He and 7.2 for DF-Hypo XE index. With the Ret-He cutoff value of < 34.0 pg and DF-Hypo XE index cutoff value of > 6.0. Receiver operating characteristic curve (ROC) analysis revealed values of the area under the curve [AUC] for Ret-He of 0.719 (p<0.05). IDA could be diagnosed with sensitivity of 71.4 %, and specificity of 63.6 %. However, [AUC] for DF-Hypo XE index of 0.636 (p>0.1), and sensitivity of 63.6 % and specificity of 58.0 % were not good. Conclusion: Ret-He is a reliable marker of cellular hemoglobin content, and is easily measurable on the widely spread and popular blood cell counter and can be used to identify the presence of iron-deficient status in dialysis patients, but DF-Hypo XE parameters is not.
*關鍵字1 ： Reticulocyte hemoglobin equivalent (Ret-He)
*關鍵字2 ： DF-Hypo XE
*關鍵字3 ： Iron deficiency anemia (IDA)
*關鍵字4 ： Haemodialysis
*關鍵字5 ： Sysmex XE-5000
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* 第一作者： 趙恒立
* 身分字號： *****89971
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