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歷 年 稿 件 內 容
 
*類別:
* 姓名: 張富傑
投稿種類: 壁報
*中文投稿標題: 利用線蟲模式尋找鮑氏不動桿菌的毒力因子
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* 投稿摘要: Acinetobacter baumannii has emerged as an important human pathogen as it causes several types of hospital acquired infections including pneumonia, meningitis, urinary tract infections, and septicemia. In this study, we applied the genetic tractable animal, C. elegans, as a model host to study the virulence of Acinetobacter baumannii as well as the host innate immunity to this pathogen. Our preliminary data showed that Acinetobacter baumannii intoxicated and eventually killed the worms. By further genetic analysis to compare the mutant strain fo Acinetobacter baumannii , we will find that some important virulence factors of Acinetobacter baumannii which was required for its toxicity in C. elegans, and some conserved innate immune signal pathways were mediated in host susceptibility. Our results suggest that this Acinetobacter baumannii/C. elegans model is suitable for future comprehensive genetic screens in both bacterial and host factors involved in the pathogenesis of Acinetobacter baumannii.
*關鍵字1 : Acinetobactor baumannii
*關鍵字2 : Virulance factor
*關鍵字3 : Caenorhabditis elegans
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* 服務機關:
* 第一作者: 張富傑
* 身分字號: *****56352
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開啟檔案
審查委員意見: the mutant strain "for"~~~有錯字
審查委員意見: OK
主任委員意見:
 
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