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歷 年 稿 件 內 容
 
*類別:
* 姓名: 李立旋
投稿種類: 壁報
*中文投稿標題: The relationship between IL-6 gene promoter polymorphism /expression in serum and occurrence of allo-immunization after blood transfusion
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*中文服務單位:
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* 投稿摘要: Transfusion may result in a production of RBC alloantibodies in recipient. The production of alloantibodies will increase not only the risk of transfusion complications, but also the difficulty in finding a compatible RBC unit for transfusion. Factors cause hosts as responders (who make alloantibodies) or non-responders (who do not make alloantibodies) after transfusion need to be identified. According to previous studies, we proposed IL-6 is highly associated with RBC alloimmunization. In this study, we evaluated the relationship of IL-6 level and its promoter SNP (-572 C/G) between the incidence of RBC alloimmunization by the method of ELISA and RFLP. Results revealed increased IL-6 expression level and the dominant G-positive (GG and CG) genotypes of IL-6 SNP (-572 C/G) in cases with alloantibodies production group. It shows that IL-6 SNP (-572 C/G) may regulate IL-6 expression level and govern the occurrence of alloimmunization after transfusion. This novel finding indicates IL-6 level or certain SNP genotype may be the risky factors of alloimmunization after transfusion. Establishing a method to identify responders before transfusion and giving them phenotyped-matched units could avoid recipients from producing antibodies.
*關鍵字1 : transfusion
*關鍵字2 : IL-6
*關鍵字3 : Alloimmunization
*關鍵字4 : Responder
*關鍵字5 : SNP
* 服務機關:
* 第一作者: 李立旋
* 身分字號: *****99397
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開啟檔案
審查委員意見: 相當有創新的研究假設和主題,需要有更多的證據來證明IL-6 expression和alloantibody 生成之關係。
審查委員意見: 無意見
主任委員意見:
 
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