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歷 年 稿 件 內 容
 
*類別：
* 姓名： 黃雅仙
投稿種類： 壁報
*中文投稿標題： 重度肥胖個案胰島素抗性、組織間隙膠原酵素-9及介白素-6與代謝異常相關性
*中文作者姓名列：
*中文服務單位：
*英文投稿標題：
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*英文服務單位：
* 投稿摘要： Obesity is currently a global epidemic associated with many health hazards. Many studies have shown that the relationship between obesity and visceral fat accumulation has effectes on the mechanisms in adipocyte inflammation. This study examines the characteristics of macrophage infiltration and inflammation biomarkers in adipose tissues and its relationship to insulin resistance among morbidly obese patients. We collected blood and omental visceral fat samples from 30 morbidly obese subjects (BMI > 35 kg/m2). In the blood samples, glucose and insulin levels were determined in order to quantify the insulin resistance using HOMA-IR(≧2.4,p=0.003). The participants were sub-divide into two groups, normal and insulin-resistant. Adipose tissue morphology and pathology were determined by using CD68 antibody immunohistochemistry (IHC) to measure the inflammation of macrophages in the omental tissue. Gene expressions of inflammation biomarkers, such as IL-6R and MMP9, were measured using real-time reverse transcriptase polymerase chain reaction (RT-PCR). In obese subjects, we was found the association between an increase in inflammatory response and insulin-resistance status. Moreover, in IR groups, higher levels of adipocyte size(r=0.921,p=0.001),cytokines IL-6R(p<0.1)and MMP9(p<0.028) were found as well as an increase in macrophage infiltration. These findings suggest that visceral fat accumulation may be linked to higher mRNA levels of IL-6R and MMP9, as well as adipose macrophage infiltration.
*關鍵字1 ： Morbidly obese
*關鍵字2 ： Visceral fat
*關鍵字3 ： biomarker inflammation
*關鍵字4 ： insulin resistance
*關鍵字5 ： macrophage infiltration
* 服務機關：
* 第一作者： 黃雅仙
* 身分字號： *****42353
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