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歷 年 稿 件 內 容
 
*類別：
* 姓名： 王秀梅
投稿種類： 壁報
*中文投稿標題： A patient with therapy- related hypogranular variant-like acute promyelocytic leukemia
*中文作者姓名列：
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*英文服務單位：
* 投稿摘要： Acute promyelocytic leukemia (APL) is an acute and critical disease usually accompanied with a risk of disseminated intravascular coagulation and high mortality. With difference from other leukemias, it’s the only leukemia dianosed by morphology exclusively. In general, WBC count less than 5000/l and a high percentage of promyelocytes with Auer rods are present in APL patients. There was a 69-year-old female patient diagnosed as APL in July 2008, which remitted after chemotherapy. In July 2012, her CBC revealed leukopenia (WBC count: 2,250 /μl), and bleeding tendency was noted. Variant promyelocytes with hypogranularity and bilobed nuclei, which morphologically seemed to be monocytes, were discovered on her blood smear. Cytogenetic study revealed t(15:17)(q24:q21). APL is classified as M3 and M3v in FAB classification. The distinct differences are the WBC counts and the granularity of the promyelocytes. The WBC counts are lower (< 5000 /μl) in the former and higher (5000 ~ 20000 /μl) in the latter; the former shows hypergranularity of the promyelocytes, in contrast, the latter shows hypo- or microgranularity. Also, they have different expression in cytogenetics. M3 possesses t(15;17), but M3v expresses t(15;variant). However, the M3v-like phenomena in this patient was mainly caused by the side-effect of chemotherapy. It is particularly important to consider the clinical and therapeutic conditions and observe atypical leukocyte morphology in patients with hematologic malignancy after chemotherapy while we perform the morphologic examination of blood and bone marrow smears.
*關鍵字1 ： APL
*關鍵字2 ： disseminated intravascular coagulation
*關鍵字3 ： Variant promyelocytes
*關鍵字4 ： bilobed nuclei
*關鍵字5 ： M3v-like
* 服務機關：
* 第一作者： 王秀梅
* 身分字號： *****92559
其他投稿作者： 黃馨儀
身分字號： *****73511
其他投稿作者： 葉智慧
身分字號： *****36532
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